本文關(guān)鍵詞：宮頸癌患者磁共振體素不相干運動相關(guān)參數(shù)變化及意義　出處：《山東醫(yī)藥》2017年40期 　論文類型：期刊論文

  更多相關(guān)文章： 宮頸癌 磁共振成像 擴散加權(quán)成像 表觀擴散系數(shù) 灌注相關(guān)體積分數(shù)

【摘要】：目的探討宮頸癌患者3.0T磁共振體素不相干運動(IVIM)相關(guān)參數(shù)變化及其診斷價值。方法選擇宮頸癌患者29例作為觀察組,體檢健康女性24例作為對照組。兩組均進行常規(guī)MRI及IVIM掃描,IVIM掃描采用13個b值,所得原始數(shù)據(jù)采用雙指數(shù)模型進行分析,記錄并比較兩組標準表觀擴散系數(shù)(標準ADC)、慢ADC、快ADC及灌注相關(guān)體積分數(shù)(f),采用受試者工作特征曲線(ROC曲線)評價各參數(shù)對宮頸癌的診斷效能。結(jié)果觀察組與對照組標準ADC分別為(0.90±0.15)×10~(-3)、(1.15±0.23)×10~(-3)mm~2/s,慢ADC分別為(0.70±0.12)×10~(-3)、(0.97±0.21)×10~(-3)mm~2/s,快ADC分別為(6.66±2.02)×10~(-3)、(5.30±1.64)×10~(-3)mm~2/s,f分別為0.29±0.09、0.45±0.11;觀察組標準ADC、慢ADC、f均低于對照組(P均0.05),兩組快ADC比較差異無統(tǒng)計學意義(P0.05)。標準ADC、慢ADC、快ADC及f診斷宮頸癌的曲線下面積分別為0.79、0.86、0.32、0.84,以慢ADC最大,其臨界值為0.89×10~(-3)mm~2/s時診斷宮頸癌的敏感性為70%、特異性為90%。結(jié)論宮頸癌患者IVIM相關(guān)參數(shù)標準ADC、慢ADC及f均降低,上述參數(shù)檢測有助于宮頸癌的診斷。
[Abstract]:Objective to investigate the changes and diagnostic value of 3. 0T magnetic resonance voxel (VMI) related parameters in patients with cervical cancer. Methods 29 patients with cervical cancer were selected as the observation group. 24 healthy women were used as control group. Both groups underwent routine MRI and IVIM scanning using 13 b values. The original data were analyzed by double index model. Two groups of standard apparent diffusion coefficients (standard ADCA, slow ADCC, fast ADC and perfusion correlation volume fraction F) were recorded and compared. The diagnostic efficacy of each parameter for cervical cancer was evaluated by using the operating characteristic curve (ROC curve). Results the standard ADC of the observation group and the control group was 0.90 鹵0.15 脳 10 ~ (-1) ~ (-3) respectively. The slow ADC was 0.70 鹵0.12 脳 10 ~ (-3) 脳 10 ~ (-3) / s (n = 1.15 鹵0.23) 脳 10 ~ (-3) / s. The ADC was 0.97 鹵0.21) 脳 10 ~ (-1) mm ~ (-3) / s, and the fast ADC was 6.66 鹵2.02 脳 10 ~ (-3)). 5.30 鹵1.64) 脳 10 ~ (-3) / m ~ (-2) / s ~ (-1) F = 0.29 鹵0.09 鹵0.45 鹵0.11, respectively; The standard ADCand slow ADCF in the observation group were lower than those in the control group (P < 0.05). There was no significant difference in fast ADC between the two groups (P < 0.05). The area under the curve of fast ADC and f for diagnosis of cervical cancer was 0.79 ~ 0.86 ~ 0.32 ~ 0.84, respectively. Slow ADC was the largest. When the critical value was 0.89 脳 10 ~ (-3) mm ~ (-1) / s, the sensitivity of diagnosis of cervical cancer was 70 and the specificity was 90. Conclusion the IVIM related parameter standard ADC for cervical cancer patients. Slow ADC and f were decreased, and the above parameters were helpful for the diagnosis of cervical cancer.
【作者單位】： 武漢大學中南醫(yī)院;荊門市第一人民醫(yī)院;
【分類號】：R445.2;R737.33
【正文快照】： 目前磁共振檢查廣泛用于宮頸癌的診斷,其中擴散加權(quán)成像(DWI)在宮頸癌的診斷、分期以及預后評估方面均具有較高的應用價值[1,2]。DWI中最常用的參數(shù)表觀擴散系數(shù)(ADC)可在一定程度上反映組織內(nèi)水分子擴散程度,但傳統(tǒng)單一指數(shù)模型具有一定局限性,例如毛細微循環(huán)無規(guī)律方向灌注

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